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Antisense - Introduction

Introduction to Antisense Antisense Applications Antisense Design/Protocol Antisense Literature Order Online

Introduction to Antisense

An antisense oligonucleotide refers to a short, synthetic DNA or RNA strand that is complementary in sequence to a short target sequence on a particular mRNA strand, which upon specific hybridization to its target induces inhibition of gene expression. The mechanism of inhibition is based on two properties: first, the physical blocking of the translation process by the presence of the short double-stranded region, and second, in the case of antisense DNA, the resulting DNA-RNA duplex is susceptible to cleavage by cellular RNase H activity, which degrades the mRNA and prevents proper translation. The latter property is the 'classic' mode of action for antisense oligos. The former property can be used when it is necessary to design an antisense oligo with certain modifications that result in it not supporting RNase-H activity (1,2).

Antisense Modifications
Product Catalog No. 50 nmol scale (XX=05) 200 nmol scale (XX=02) 1 mmol scale (XX=01) 2 mmol scale (XX=03) 10 mmol scale (XX=10) 15 mmol scale (XX=15)

2'-Fluoro deoxyadenosine (2'-F-A)

26-6692

$38.00

$38.00

$57.00

$85.50

$456.00

$570.00

2'-Fluoro deoxycytosine (2'-F-C)

26-6463

$28.00

$28.00

$36.40

$54.60

$291.20

$364.00

2'-Fluoro deoxyguanosine (2'-F-G)

26-6693

$38.00

$38.00

$57.00

$85.50

$456.00

$570.00

2'-Fluoro deoxyuridine (2'-F-U)

26-6462

$28.00

$28.00

$36.40

$54.60

$291.20

$364.00

2'-O methyl adenosine A

27-6410A

$6.00

$8.00

$16.00

$28.00

$102.00

$148.00

2'-O methyl cytosine C

27-6410C

$6.00

$8.00

$16.00

$28.00

$102.00

$148.00

2'-O methyl guanosine G

27-6410G

$6.00

$8.00

$16.00

$28.00

$102.00

$148.00

2'-O methyl uridine U

27-6410U

$6.00

$8.00

$16.00

$28.00

$102.00

$148.00

3'-rA (2'-5' linked)

26-6682

$88.40

$88.40

$114.92

$172.38

$919.36

$1,149.20

5-methyl deoxycytosine (5Me-dC)

26-6413

$49.00

$49.00

$63.70

$95.55

$509.60

$637.00

Cholesterol TEG (15 atom triethylene glycol spacer)

26-6602

$324.50

$324.50

$421.85

$632.77

$3,374.80

$4,218.50

Methyl Phosphonate

26-6510

$65.00

$65.00

$84.50

$126.75

$676.00

$845.00

phosphorothioate

26-6401

$3.50

$4.25

$6.50

$9.00

$52.00

$65.00

Phosphorylation-3'

26-6427

$55.00

$55.00

$110.00

$200.00

$880.00

$1,100.00

Phosphorylation-5'

26-6428

$20.00

$25.00

$45.00

$67.50

$180.00

$270.00


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