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Cross-Linkers - Introduction

Introduction to Cross-Linkers Cross-Linkers Applications Cross-Linkers Design/Protocol Cross-Linkers Literature Order Online

Introduction to Cross-Linkers

The ability to utilize UV light to cross-link bases in double-stranded and triple-stranded DNA, or cross-link bases in oligonucleotides with other types of molecules (such as proteins), is often a necessary for successful performance of structural studies, for example the probing of nucleic acid secondary structure, or the structure of protein-nucleic acid complexes. Cross-linker modifications generally fall into two categories, nucleic acid intercalators (for example, psoralen) and halogenated bases (for example, 5-Br-dC). Incorporation of a nucleic acid intercalator into an oligo permits site-specific targeting of the cross-link into double-stranded and triple-stranded DNA. Incorporation of a modified base, capable of forming cross-links, into an oligonucleotide is often the method of choice when an intra-strand cross-link is needed, or a direct cross-link to a protein or other molecule is desired.

Cross-Linkers Modifications
Product Catalog No. 50 nmol scale (XX=05) 200 nmol scale (XX=02) 1 mmol scale (XX=01) 2 mmol scale (XX=03) 10 mmol scale (XX=10) 15 mmol scale (XX=15)

5-bromo deoxycytosine (Br dC)

26-6411

$78.00

$78.00

$101.40

$152.10

$811.20

$1,014.00

5-bromo deoxyuridine (Br-dU)

26-6412

$78.00

$78.00

$101.40

$152.10

$811.20

$1,014.00

5-Iodo deoxycytosine dC

26-6414

$162.00

$162.00

$210.60

$315.90

$1,684.80

$2,106.00

5-iodo deoxyuridine dU

26-6415

$78.00

$78.00

$101.40

$152.10

$811.20

$1,014.00

Convertible dG (2-Fluoro deoxy inosine)

26-6671

$360.00

$360.00

$468.00

$702.00

$3,744.00

$4,680.00

Psoralen C6

26-6686

$234.00

$234.00

$304.20

$456.30

$2,433.60

$3,042.00


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