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Cross-Linkers - Introduction

Introduction to Cross-Linkers Cross-Linkers Applications Cross-Linkers Design/Protocol Cross-Linkers Literature Order Online

Introduction to Cross-Linkers

The ability to utilize UV light to cross-link bases in double-stranded and triple-stranded DNA, or cross-link bases in oligonucleotides with other types of molecules (such as proteins), is often a necessary for successful performance of structural studies, for example the probing of nucleic acid secondary structure, or the structure of protein-nucleic acid complexes. Cross-linker modifications generally fall into two categories, nucleic acid intercalators (for example, psoralen) and halogenated bases (for example, 5-Br-dC). Incorporation of a nucleic acid intercalator into an oligo permits site-specific targeting of the cross-link into double-stranded and triple-stranded DNA. Incorporation of a modified base, capable of forming cross-links, into an oligonucleotide is often the method of choice when an intra-strand cross-link is needed, or a direct cross-link to a protein or other molecule is desired.

Cross-Linkers Modifications

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Product Code Catalog No. 50 nmol scale (XX=05) 200 nmol scale (XX=02) 1 mmol scale (XX=01) 2 mmol scale (XX=03) 10 mmol scale (XX=10) 15 mmol scale (XX=15)

5-bromo deoxycytosine (Br dC)

[5-Br-dC]

26-6411

$84.00

$84.00

$110.00

$164.00

$876.00

$1,095.00

5-bromo deoxyuridine (Br-dU)

[5Br-dU]

26-6412

$84.00

$84.00

$110.00

$164.00

$876.00

$1,095.00

5-Iodo deoxycytosine dC

[5-I dC]

26-6414

$175.00

$300.00

$227.00

$341.00

$1,820.00

$2,274.00

5-iodo deoxyuridine dU

[5-I-dU]

26-6415

$84.00

$144.00

$110.00

$164.00

$876.00

$1,095.00

Convertible dG (2-Fluoro deoxy inosine)

[2-FdI]

26-6671

$489.00

$489.00

$676.00

$758.00

$4,044.00

$5,054.00

Psoralen C6-5'

[Pso-C6-5]

26-6686

$210.00

$210.00

$280.00

$369.00

$1,438.00

$1,797.00

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