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Halogenated Bases - Introduction

Introduction to Halogenated Bases Halogenated Bases Applications Halogenated Bases Design/Protocol Halogenated Bases Literature Order Online

Introduction to Halogenated Bases

Halogenated nucleotides, for example, 5-Br-dC, 5-I-dU, are modified with a halogen on the base (NOT the ribose). Halogenated nucleotides are incorporated into oligonucleotides for determining DNA/RNA structural characteristics by X-ray crystallography (1). In addition, because they are photo-labile, oligonucleotides modified with halogenated bases can be UV cross-linked with other molecules, for example proteins, in order to investigate the structure and function of complexes between DNA and the other molecules (2). This property of photo-lability can also be taken advantage of in aptamer development, where halogenated bases can be incorporated into an aptamer, post-SELEX, to create a photo-aptamer. Such photo-aptamers still retain essentially the same binding affinity for their target, but are now capable of being UV cross-linked to those targets (3).

Halogenated Bases Modifications
Product Catalog No. 50 nmol scale (XX=05) 200 nmol scale (XX=02) 1 mmol scale (XX=01) 2 mmol scale (XX=03) 10 mmol scale (XX=10) 15 mmol scale (XX=15)

5-bromo deoxycytosine (Br dC)

26-6411

$78.00

$78.00

$101.40

$152.10

$811.20

$1,014.00

5-bromo deoxyuridine (Br-dU)

26-6412

$78.00

$78.00

$101.40

$152.10

$811.20

$1,014.00

5-Fluoro deoxyuridine dU

26-6416

$110.00

$110.00

$143.00

$214.50

$1,144.00

$1,430.00

5-Iodo deoxycytosine dC

26-6414

$162.00

$162.00

$210.60

$315.90

$1,684.80

$2,106.00

5-iodo deoxyuridine dU

26-6415

$78.00

$78.00

$101.40

$152.10

$811.20

$1,014.00


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