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Halogenated Bases - Introduction

Introduction to Halogenated Bases Halogenated Bases Applications Halogenated Bases Design/Protocol Halogenated Bases Literature Order Online

Introduction to Halogenated Bases

Halogenated nucleotides, for example, 5-Br-dC, 5-I-dU, are modified with a halogen on the base (NOT the ribose). Halogenated nucleotides are incorporated into oligonucleotides for determining DNA/RNA structural characteristics by X-ray crystallography (1). In addition, because they are photo-labile, oligonucleotides modified with halogenated bases can be UV cross-linked with other molecules, for example proteins, in order to investigate the structure and function of complexes between DNA and the other molecules (2). This property of photo-lability can also be taken advantage of in aptamer development, where halogenated bases can be incorporated into an aptamer, post-SELEX, to create a photo-aptamer. Such photo-aptamers still retain essentially the same binding affinity for their target, but are now capable of being UV cross-linked to those targets (3).

Halogenated Bases Modifications

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Product Code Catalog No. 50 nmol scale (XX=05) 200 nmol scale (XX=02) 1 mmol scale (XX=01) 2 mmol scale (XX=03) 10 mmol scale (XX=10) 15 mmol scale (XX=15)

5-bromo ribocytosine (5-Br C)

[5-Br-rC]

27-6551

$227.00

$227.00

$259.00

$367.00

$875.00

$1,296.00

5-bromo deoxycytosine (Br dC)

[5-Br-dC]

26-6411

$84.00

$84.00

$110.00

$164.00

$876.00

$1,095.00

5-bromo deoxyuridine (Br-dU)

[5Br-dU]

26-6412

$84.00

$84.00

$110.00

$164.00

$876.00

$1,095.00

5-bromo ribouridine (5-Br rU)

[5-Br-rU]

27-6552

$227.00

$227.00

$259.00

$367.00

$875.00

$1,296.00

5-Fluoro deoxyuridine dU

[5-F-dU]

26-6416

$246.00

$246.00

$310.00

$410.00

$1,236.00

$1,760.00

5-Iodo ribocytosine (5-I C)

[5-I-rC]

27-6553

$227.00

$227.00

$259.00

$367.00

$875.00

$1,296.00

5-Iodo deoxycytosine dC

[5-I dC]

26-6414

$175.00

$300.00

$227.00

$341.00

$1,820.00

$2,274.00

5-iodo deoxyuridine dU

[5-I-dU]

26-6415

$84.00

$144.00

$110.00

$164.00

$876.00

$1,095.00

5-Iodo ribouridine (5-I U)

[5-I-rU]

27-6554

$227.00

$227.00

$259.00

$367.00

$875.00

$1,296.00

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