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2'-O-methoxy-ethyl 5me Cytidine-(2'-MOE meC)

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picture of 2'-O-methoxy-ethyl 5me Cytidine-(2'-MOE meC)

Modification : 2'-MOE-5mC

Catalog Reference Number
Modification Code
5 Prime
3 Prime
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC


Catalog NoScalePrice
27-6450mC-0550 nmol$14.25
27-6450mC-02200 nmol$14.25
27-6450mC-011 umol$16.50
27-6450mC-032 umol$26.00
27-6450mC-1010 umol$110.00
27-6450mC-1515 umol$138.00

Antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) are both recognized therapeutic agents for the silencing of specific genes at the posttranscriptional level. Chemical modifications, particularly 2-O-(2-Methoxyethyl)- oligoribonucleotides (2-O-MOE bases) and 2-O-Methyl bases are commonly used to confer nuclease resistance to an oligo designed for anti-sense, siRNA or aptamer-based research, diagnostic or therapeutic purposes, when specific 2-OH is not required.
Nuclease resistance can be further enhanced by phosphorothiolation of appropriate phosphodiester linkages within the oligo. These modifications confers nuclease resistance, high binding affinity towards complementary RNA, reduced unspecific protein binding and extended half-life in tissues.
Gapmers. Currently, the mainstream of the ASO is gapmer design ASOs. Gapmer design oligonucleotides, contain two to five chemically modified nucleotides (LNA, 2-O methyl or 2-O-MOE RNA) as wings at each terminus flanking a central 5- to10-base gap of DNA, enable cleavage of the target mRNA by RNase H, which recognizes DNA/RNA heteroduplexes. Usually all the phosphodiester linkages are converted to phosphorothioate.
Delivery. The development of effective delivery systems for antisense oligonucleotides is essential for their clinical therapeutic application. The most common delivery system involves a relatively hydrophobic molecule that can cross the lipid membrane. The following list of modifications are suitable for delivery system in addition to cell penetrating peptides.
Tocopherol (alpha-tocopherol, a natural isomer of vitamin E)

- 2'-O-methoxy-ethyl 5me Cytidine-(2'-MOE meC)

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