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In this section: Introduction | Genemerâ„¢ | GeneProberâ„¢ | Proberâ„¢ Gene Detection Kits | GScanâ„¢ Gene Detection Kits | Genemerâ„¢ Control DNA | Infectious Diseases
In this section: Gene Construction
In this section: Introduction | The Omni-Cleanâ„¢ System | The Omni-Pureâ„¢ Plasmid Purification System | The Omni-Pureâ„¢ Genomic DNA Purification System | Viral DNA & RNA Purification | Microbial DNA Purification | Plant DNA Purification
In this section: Introduction | Quality Control | Purification | Modifications | Long Oligos | Price List
In this section: Introduction | Molecular Beacon FAQ's | Fluorescent Probes Price List | Other Fluorescent Molecular Probes
In this section: SPCT | DME SPCT Intro | Order DME TaqMan® Assays SPCT | SNP PCT Search | Gene Expression Assays | SPCT Design Center | GeneAssays
In this section: RNA Oligonucleotides | Quality Control | Purification | Modifications | RNAi Explorerâ„¢ Products and Prices | Custom RNAi | RNAi Design Guidelines | SmartBaseâ„¢ siRNA Modifications | shRNA Explorerâ„¢
In this section: PCR Amplification & Analysis
In this section: Introduction | Genemerâ„¢ | GeneProberâ„¢ | Proberâ„¢ Gene Detection Kits | GScanâ„¢ Gene Detection Kits | Genemerâ„¢ Control DNA | Infectious Diseases
In this section: Gene Construction
In this section: Introduction | The Omni-Cleanâ„¢ System | The Omni-Pureâ„¢ Plasmid Purification System | The Omni-Pureâ„¢ Genomic DNA Purification System | Viral DNA & RNA Purification | Microbial DNA Purification | Plant DNA Purification
3'-rG (2'-5' linked)
Modification : 3'-rG (2'-5' linked)
Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC
26-6912
Minor Bases
3'-rG(2'-5')
Y
Y
Y
345.21
11.5
PS26-6912.pdf
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Catalog No | Scale | Price | 26-6912-05 | 50 nmol | $88.40 | 26-6912-02 | 200 nmol | $88.40 | 26-6912-01 | 1 umol | $114.92 | 26-6912-03 | 2 umol | $172.38 | 26-6912-10 | 10 umol | $919.36 | 26-6912-15 | 15 umol | $1,149.20 | 26-6912-15 | 15 umol | $1,149.20 |
Discounts are available for 3'-rG (2'-5' linked) ! |
Modification* Discount Price Structure |
1 site/order
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List price
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2 sites/order
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10% discount
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3 sites/order
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20% discount
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4 sites/order
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30% discount
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5-9 sites/order
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50% discount
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10+ sites/order
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60% discount
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*Exceptions apply
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3'-riboguanosine (3’-rG)–(2'-5' linked), and the other three 3’-ribonucleotide (2’,5’-linked) modifications are used to substitute 2’-5’ phosphodiester linkages for the usual 3’-5’ phosphodiester linkages at some or all positions of an oligonucleotide. Oligonucleotides containing all, or primarily, 2’,5’-phosphodiester linkages selectively bind to complementary single-stranded 3’,5’-RNA over comparable 3’,5’-DNA (1). Presumably this selectively is a consequence of the 2’,5’-linkages destabilizing duplexes formed with 3’,5’-DNA more than those formed with 3’,5’-RNA, leading to 2’5’-RNA:3’,5’-DNA duplexes having much lower Tm than the corresponding 2’5’-RNA:3’,5’-RNA duplexes. This property means that RNA oligos containing such linkages could be useful in anti-sense applications, as ssRNA-specific probes, or as ligands for affinity purification of cellular RNA.
References
1. Giannaris, P.A.; Damha, M.J. Oligoribonucleotides containing 2’,5’-phosphodiester linkages exhibit binding selectivity for 3’,5’-RNA over 3’,5’-ssDNA. Nucleic Acids Res (1993), 21: 4742-4749.
- 3'-rG (2'-5' linked)
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