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Custom Oligonucleotide Synthesis

Conjugation Chemistry & End Modifiers

All modifications can be broadly termed as end modifiers as these modify the 5’ or 3’ end. This section contains a list of modifications that are used to modify the ends for conjugation to other modifications or to solid surfaces including magnetic beads. The end modifiers add a reactive functional group which can be used for conjugation. The common functional groups that can be added are amino, carboxyl, maleimide and thiol. All of these can be combined with different length of spacers (C3, C12, Spacer 9 and 18) to add physical distance of the functional group from the end of the oligonucleotide sequence.

Modifications for Oligo Synthesis
Product Code Catalog No. 50 nmol scale (XX=05) 200 nmol scale (XX=02) 1 umol scale (XX=01) 2 umol scale (XX=03) 10 umol scale (XX=10) 15 umol scale (XX=15)
5-Carboxy-C10 [Ca-C10] 26-6717 $64.00 $64.00 $96.00 $144.00 $720.00 $936.00
Adenylation-5' (rApp) [5rApp] 26-6805 $475.00 $475.00 $1,125.00 $1,865.00 $9,000.00 $11,250.00
Amino Allyl [AmAllyl] 26-6731 $210.00 $210.00 $256.00 $310.00 $1,550.00 $1,755.00
Amino Linker C12 [AmC12] 26-6420 $117.00 $117.00 $152.10 $228.15 $1,216.80 $1,521.00
Amino Linker C3 [AmC3] 26-6405 $45.00 $45.00 $58.50 $87.75 $468.00 $585.00
Amino Linker C6 [AmC6] 26-6418 $24.00 $24.00 $58.50 $66.80 $249.60 $312.00
Amino Linker C7 [AmC7] 26-6406 $45.00 $45.00 $58.50 $87.75 $468.00 $585.00
Amino modifier serinol [AmSr] 26-6715 $247.50 $247.50 $321.75 $482.62 $2,574.00 $3,217.50
Aminooxy-Modifier-11 [AmOx] 26-6948 $318.00 $318.00 $413.40 $620.10 $3,307.20 $4,134.00
Brancher levulinyl 5-me dC [Brn-LEV-dC] 26-6610 $410.00 $410.00 $524.00 $665.00 $1,410.00 $1,645.00
Cholesterol TEG (15 atom triethylene glycol spacer) [CholTEG] 26-6602 $175.00 $175.00 $210.00 $265.00 $987.00 $126.00
iso deoxycytosine (iso dC) [iso dC] 26-6992 $351.00 $351.00 $456.30 $684.45 $3,650.40 $4,563.00
Magnetic Bead Oligo Conjugation [Mag-Oligo] 26-7015 Inquire Inquire $550.00 $850.00 Inquire Inquire
Maleimide-Modifier (5') [Mal] 26-6574 $105.00 $105.00 $136.50 $204.75 $816.00 $1,368.00
NHS-Carboxy C10 5' [NHS-Ca C10] 26-6452 $96.00 $96.00 $124.80 $187.20 $998.40 $1,248.00
NHS-Carboxy-dT [NHS-CO dT] 26-6453 $226.00 $226.00 $293.80 $440.70 $2,350.40 $2,938.00
Thiol SS-C3 [SS-C3] 26-6482 $210.00 $210.00 $290.00 $395.00 $2,127.00 $2,450.00
Thiol SS-C6 [SS-C6] 26-6419 $98.00 $98.00 $127.40 $191.10 $1,019.00 $1,274.00
Universal Support (CPG) [Univ] 26-6575 $18.75 $18.75 $24.37 $37.00 $195.00 $244.00
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