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Oligonucleotide Synthesis with End Modifiers

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Conjugation Chemistry

All modifications can be broadly termed as end modifiers as these modify the 5’ or 3’ end. This section contains a list of modifications that are used to modify the ends for conjugation to other modifications or to solid surfaces including magnetic beads. The end modifiers add a reactive functional group which can be used for conjugation. The common functional groups that can be added are amino, carboxyl, maleimide and thiol. All of these can be combined with different length of spacers (C3, C12, Spacer 9 and 18) to add physical distance of the functional group from the end of the oligonucleotide sequence.

Modifications for Oligo Synthesis
Product Code Catalog No. 50 nmol scale (XX=05) 200 nmol scale (XX=02) 1 umol scale (XX=01) 2 umol scale (XX=03) 10 umol scale (XX=10) 15 umol scale (XX=15)
5'-Amino dT [5-Am-dT] 26-6657T $210.00 $210.00 $245.00 $286.00 $610.00 $785.00
5-Carboxy-C10 [CO-C10] 26-6717 $136.00 $136.00 $185.00 $210.00 $778.00 $1,011.00
Adenylation-5' (rApp) [5rApp] 26-6805 $513.00 $513.00 $1,215.00 $2,014.00 $9,720.00 $12,150.00
Amino Allyl [AmAllyl] 26-6731 $227.00 $227.00 $276.00 $335.00 $1,674.00 $1,895.00
Amino Mod C12-5' [AmC12] 26-6420 $126.00 $126.00 $164.00 $246.00 $1,314.00 $1,643.00
Amino Mod C3 Internal [AmC3-Int] 26-6405N $85.00 $85.00 $119.00 $142.00 $714.00 $856.00
Amino Mod C3-3' [AmC3-3] 26-6405T $85.00 $85.00 $119.00 $142.00 $714.00 $856.00
Amino Mod C3-5 [AmC3-5] 26-6405F $85.00 $85.00 $119.00 $142.00 $714.00 $856.00
Amino Mod C6 [AmC6] 26-6418 $85.00 $85.00 $119.00 $142.00 $714.00 $856.00
Amino modifier serinol [Am-Ser] 26-6715 $289.00 $289.00 $347.00 $563.00 $3,002.00 $3,753.00
Amino Spacer 7 C6 Internal [AmSp7-C6-Int] 26-6560 $227.00 $227.00 $406.00 $620.00 $2,484.00 $3,408.00
Amino Spacer 7-C6 (3') [AmSp7-C6] 26-6425 $49.00 $49.00 $63.00 $95.00 $505.00 $632.00
Aminooxy-Modifier-11 [AmOx] 26-6948 $343.00 $343.00 $446.00 $670.00 $3,572.00 $4,465.00
Brancher levulinyl 5-me dC [Brn-LEV-mdC] 26-6610 $443.00 $443.00 $566.00 $718.00 $1,523.00 $1,777.00
iso deoxycytosine (iso dC) [iso-dC] 26-6992 $379.00 $379.00 $493.00 $739.00 $3,942.00 $4,928.00
Magnetic Bead Oligo Conjugation [Mag-Oligo] 26-7015 $486.00 $486.00 $594.00 $918.00 $4,104.00 $4,860.00
Maleimide-Modifier (5') [Mal] 26-6574 $113.00 $113.00 $147.00 $221.00 $881.00 $1,477.00
NHS-Carboxy C10 5' [NHS-CO-C10] 26-6452 $104.00 $104.00 $135.00 $202.00 $1,078.00 $1,348.00
NHS-Carboxy-dT [NHS-CO-dT] 26-6453 $341.00 $341.00 $386.00 $476.00 $2,538.00 $3,173.00
Thiol SS-C3 [SS-C3] 26-6482 $227.00 $227.00 $313.00 $427.00 $2,297.00 $2,646.00
Thiol SS-C6 [SS-C6] 26-6419 $106.00 $106.00 $138.00 $206.00 $1,101.00 $1,376.00
Universal Support (CPG) [Univ] 26-6575 $20.00 $20.00 $26.00 $40.00 $211.00 $264.00
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