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Amino modifier serinol

picture of Amino modifier serinol

Modification : Amino Serinol

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



26-6715
End Modifiers
Am Sr
Y
Y
Y
224.15
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PS26-6715.pdf
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Catalog NoScalePrice
26-6715-0550 nmol$247.50
26-6715-02200 nmol$247.50
26-6715-011 umol$321.75
26-6715-032 umol$482.62
26-6715-1010 umol$2,574.00
26-6715-1515 umol$3,217.50
Discounts are available for Amino Serinol!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Amino-Modifier Serinol can be used to add amino groups at the 5' end or at the 3' end of long oligos that require CPG with pore size of greater than 1000 Angstrom that are not available. The synthesis is started with a T 3000 Angstrom base CPG followed amino serinol coupling with synthesis continued till the 5'-end. Upon deprotection the 3'-T base is automatically removed leaving a priamry amino group.
The presence of the primary amino group allows the user to label the oligo with a variety of different ligands for affinity, reporter or protein moieties (as NHS esters or isothiocyanates), depending on the application. Examples include biotin, digoxigenin, and fluorescent dyes or quenchers, magnetic beads and enzymes (for example, alkaline phosphatase).



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The primary amine labelled oligos can also be conjugated to carboxyl functional groups usually for solid supports applications using EDC mediated reaction as shown in the figure below.





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The primary amine labelled oligos can also be conjugated to carboxyl functional groups usually for solid supports applications using EDC mediated reaction as shown in the figure below.



- Amino modifier serinol

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