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SmartBaseTM siRNA & ASO

SmartBaseTM siRNA & ASO Single Strand & Duplex Price List

Click here to see a list of siRNA and antisense oligo modifications.


The SmartBaseTM The SmartBaseTM siRNA oligos provided are synthesized as a single strand oligo with appropriate modifications to impart nuclease resistance and duplex stability. These include select phosphodiester linkages substituted by phosphorothioate linkages, modified 2'F and 2'O methyl bases. Gene Link provides single stranded and duplex siRNA's. For duplex siRNA, the single stranded siRNA oligos are annealed after complete deprotection and purification steps are completed. Gene Link utilizes the most reliable standard RNA synthesis chemistry. The SmartBaseTM siRNA duplexes are supplied lyophilized and ready to use after reconstitution. Gene Link offers numerous modifications e.g GalNAc. Cholesterol TEG etc for cellular delivery and effective siRNA functions.
Gene Link can synthesize gram quatities of SmartBaseTM siRNA oligos.

Custom SmartBaseTM siRNA& ASO Single Strand Price List**

Size

Standard Purity*

RPC Purified*

PAGE Purified*

A260 Units

mg

nmols

Price

Catalog No.

Price

Catalog No. Price

Catalog No

~1.25
~0.04
5 nmol
$127.50
27-6736-05S
$190.00
27-6737-05S
$340.00
27-6738-05S
~2.5
~0.07
10 nmol
$177.50
27-6736-10S
$240.00
27-6737-10S
$462.50
27-6738-10S
~5
~0.14
20 nmol
$195.00
27-6736-20S
$305.00
27-6737-20S
$600.00
27-6738-20S
~7.5
~0.23
30 nmol
$235.00
27-6736-30S
$340.00
27-6737-30S
$650.00
27-6738-30S
~10
~0.38
50 nmol
$265.00
27-6736-50S
$387.50
27-6737-50S
$755.00
27-6738-50S
~20
~0.75
100 nmol
$305.50
27-6736-01S
$427.50
27-6737-01S
$1,225.00
27-6738-01S
~30
~1.10
150 nmol
$345.00
27-6736-15S
$580.50
27-6737-15S
$1,660.00
27-6738-15S
*Please see table below for description of purity levels for standard purity, RPC and gel purified.
** Above pricing is for single strand siRNA up to 26mer with 2'Fluoro, 2'O methyl and phosphorothiaote linkages. Additional per base charges of $4.00 apply for longer siRNA and all other modifications including standard RNA bases. R NA bases charges of minimum of 15mer per oligo. DNA bases at no additional cost.

Click here to see a list of siRNA and antisense oligo modifications.

siRNA Duplexed Purity Levels
Standard Purity RPC Purified** Gel Purified

Purity is greater than 75%
depending on oligo sequence and structure.

Reverse phase purification recommended.

Gel purification recommended to achieve purity above 95%.

Purity 85% to 95% depending on oligo sequence and structure. Yield and purity will be lower for sequences with high GC content

**RPC is reverse phase purification using a cartridge; a substitue for HPLC.

Purity 98% to ~100% depending on oligo sequence and structure.

Palindromes, hairpins and high GC content oligos and oligos containing stretches of 3 or more G's induce strong secondary structure and base stacking thus decreasing purity and yield.


Custom SmartBaseTM siRNA Duplex Price List**

Size

Standard Purity*

RPC Purified*

PAGE Purified*

A260 Units

mg

nmol

Price

Catalog No.

Price

Catalog No. Price

Catalog No

~2.5
~0.08
5 nmol
$254.00
27-6736-05
$380.00
27-6737-05
$680.00
27-6738-05
~5.0
~0.14
10 nmol
$355.00
27-6736-10
$480.00
27-6737-10
$925.00
27-6738-10
~10.0
~0.28
20 nmol
$390.00
27-6736-20
$610.00
27-6737-20
$1,200.00
27-6738-20
~15
~0.46
30 nmol
$470.00
27-6736-30
$680.00
27-6737-30
$1,300.00
27-6738-30
~20
~0.76
50 nmol
$530.00
27-6736-50
$775.00
27-6737-50
$1,510.00
27-6738-50
~40
~1.5
100 nmol
$610.00
27-6736-01
$985.00
27-6737-01
$2,450.00
27-6738-01
~60
~2
150 nmol
$690.00
27-6736-15
$1,280.00
27-6737-15
$3,185.00
27-6738-15
*Please see table below for description of purity levels for standard purity, RPC and gel purified.
** Above pricing is for duplex siRNA up to 26mer with 2'Fluoro, 2'O methyl and phosphorothiaote linkages. Additional per base charges of $4.00 apply for longer siRNA and all other modifications including standard RNA bases. RNA bases charges of minimum of 15mer per oligo. DNA bases at no additional cost.

Click here to see a list of siRNA and antisense oligo modifications.

SmartBaseTM siRNA & ASO Scale of Synthesis Synthesis & Yield List

 

Crude Desalted

RPC Purified

Gel Purified

Scale of Synthesis

nmols

mg

A260 Units

nmols

mg

A260 Units

nmols

mg

A260 Units

50 nmols

~10

~0.06

~2

~5

~0.03

~1

~0.5

~0.003

~0.1

200 nmols

~30

~0.2

~7

~15

~0.1

~3.5

~5

~0.03

~1

1 umol

~150

~0.8

~25

~75

~0.4

~12

~25

~0.16

~5.5

10 umol

~1500

~8

~250

~600

~3.2

~110

~250

~1.16

~55

15 umol

~2250

~12

~375

~900

~5

~180

~375

~2.4

~82

Purity is greater than 75% depending on oligo sequence and structure. Reverse phase purification recommended for greater than 85% purity. Gel purification recommended to achieve purity above 95%.

Purity 85% to 95% depending on oligo sequence and structure. Yield and purity will be lower for sequences with high GC content **RPC is reverse phase purification using a cartridge; a substitue for HPLC.

Purity +98% depending on oligo sequence and structure. Palindromes, hairpins and high GC content oligos and oligos containing stretches of 3 or more G's induce strong secondary structure and base stacking thus decreasing purity and yield.

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