8-Amino-dG

Code : [8-Am-dG]

Modification : 8-Amino-dG

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC

26-6534
Structural Studies
[8-Am-dG]
Y
Y
Y
344.22
11.5
PS26-6534.pdf
-
-
-

Catalog No	Scale	Price
26-6534-05	50 nmol	$443.00
26-6534-02	200 nmol	$443.00
26-6534-01	1 umol	$576.00
26-6534-03	2 umol	$853.00
26-6534-10	10 umol	$4,609.00
26-6534-15	15 umol	$5,761.00

Discounts are available for 8-Amino-dG!
Modification* Discount Price Structure
1 site/order	List price
2 sites/order	10% discount
3 sites/order	20% discount
4 sites/order	30% discount
5-9 sites/order	50% discount
10+ sites/order	60% discount
*Exceptions apply

Related Modifications
2'-O methyl G	2'-O methyl U	5-Me iso dC
propyne dU	8-Amino-dG	pseudoU-2'deoxy
2'-O methyl A	7-deaza-8-aza-dA	2'-O methyl C
Thio 6-dG (s6dG)	7-deaza-dX	propyne dC
8-amino-dA

8-Amino-deoxyGuanosine (8-Amino-dG) is an 8-amino-purine that is most commonly used to study the structural and functional properties of triple helices. The 8-amino group is able to form an additional Hoogsteen purine-pyrimidine hydrogen bond, which serves to increase triple helix stability (1). 8-Amino-dG-modified oligonucleotides are also used in oxidative DNA damage/repair studies. The industrial solvent 2-nitropropane generates 8-Amino-dG as a DNA lesion, which in this initial study appears to be weakly mutagenic (2).

References
1. Cubero, E., Avino, A., de la Torre, B.G., Frieden, M., Eritja, R., Luque, F.J., Gonzalez, C., Orozco, M. Hoogsteen-based parallel-stranded duplexes of DNA. The effect of 8-amino derivatives. J. Am. Chem. Soc. (2002), 124: 3133-3142.
2. Venkatarangan, L., Sivaprasad, A., Johnson, F., Basu, A.K. Site-specifically located 8-amino-2�-deoxyguanosine: thermodynamic stability and mutagenic properties in Escherichia coli. Nucleic Acids Res. (2001), 29: 1458-1463.
- 8-Amino-dG