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In this section: Introduction | The Omni-Cleanâ„¢ System | The Omni-Pureâ„¢ Plasmid Purification System | The Omni-Pureâ„¢ Genomic DNA Purification System | Viral DNA & RNA Purification | Microbial DNA Purification | Plant DNA Purification
In this section: Introduction | Quality Control | Purification | Modifications | Long Oligos | Price List
In this section: Introduction | Molecular Beacon FAQ's | Fluorescent Probes Price List | Other Fluorescent Molecular Probes
In this section: SPCT | DME SPCT Intro | Order DME TaqMan® Assays SPCT | SNP PCT Search | Gene Expression Assays | SPCT Design Center | GeneAssays
In this section: RNA Oligonucleotides | Quality Control | Purification | Modifications | RNAi Explorerâ„¢ Products and Prices | Custom RNAi | RNAi Design Guidelines | SmartBaseâ„¢ siRNA Modifications | shRNA Explorerâ„¢
In this section: PCR Amplification & Analysis
In this section: Introduction | Genemerâ„¢ | GeneProberâ„¢ | Proberâ„¢ Gene Detection Kits | GScanâ„¢ Gene Detection Kits | Genemerâ„¢ Control DNA | Infectious Diseases
In this section: Gene Construction
In this section: Introduction | The Omni-Cleanâ„¢ System | The Omni-Pureâ„¢ Plasmid Purification System | The Omni-Pureâ„¢ Genomic DNA Purification System | Viral DNA & RNA Purification | Microbial DNA Purification | Plant DNA Purification
7-deaza-dX
Modification : 7-deaza-dX
Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC
26-6536
Triplex Stability
[7-deaza-dX]
Y
Y
Y
329.21
10.6
PS26-6536.pdf
1
1
1
Catalog No | Scale | Price | 26-6536-05 | 50 nmol | $355.00 | 26-6536-02 | 200 nmol | $355.00 | 26-6536-01 | 1 umol | $461.50 | 26-6536-03 | 2 umol | $692.25 | 26-6536-10 | 10 umol | $3,692.00 | 26-6536-15 | 15 umol | $4,615.00 |
Discounts are available for 7-deaza-dX! |
Modification* Discount Price Structure |
1 site/order
|
List price
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2 sites/order
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10% discount
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3 sites/order
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20% discount
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4 sites/order
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30% discount
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5-9 sites/order
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50% discount
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10+ sites/order
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60% discount
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*Exceptions apply
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7-deaza-deoxyxanthosine (7-deaza-dX) is a deoxyribonucleoside in which the 7-nitrogen (N7) of the base is replaced by C-H. The resulting modified dX is unable to form a hydrogen bond at position 7. 7-deaza-dX is a useful research tool for DNA structural studies. For example, in one study on triple helix formation, the authors showed that 7-deaza-X:A-T triplets are stable and can be used to facilitate formation of triple helices in the anti-parallel motif (1). In a different study related to development of an expanded genetic alphabet, the ability of 7-deaza-dX to form non-standard base pair with an 2,4-diaminopyrimidine analog (2). Note that in both studies, their authors used H-phosphonate chemistry to incorporate 7-deaza-dX into the oligonucleotide.
References
1. Milligan, J.F., Krawczyk, S.H., Wadwani, S., Matteucci, M.D. An anti-parallel triple helix motif with oligodeoxynucleotides containing 2-deoxyguanosine and 7-deaza-2’-deoxyxanthosine. Nucleic Acids Res. (1993), 21: 327-333.
2. Lutz, M.J., Held, H.A., Hottiger, M., Hubscher, U., Benner, S.A. Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet. Nucleic Acids Res. (1996), 24: 1308-1313.
- 7-deaza-dX
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