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7-deaza-dX

picture of 7-deaza-dX

Modification : 7-deaza-dX

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



26-6536
Triplex Stability
7-deaza-dX
Y
Y
Y
329.21
1
PS26-6536.pdf
1
1
1


Catalog NoScalePrice
26-6536-0550 nmol$355.00
26-6536-02200 nmol$355.00
26-6536-011 umol$461.50
26-6536-032 umol$692.25
26-6536-1010 umol$3,692.00
26-6536-1515 umol$4,615.00
Discounts are available for 7-deaza-dX!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

7-deaza-deoxyxanthosine (7-deaza-dX) is a deoxyribonucleoside in which the 7-nitrogen (N7) of the base is replaced by C-H. The resulting modified dX is unable to form a hydrogen bond at position 7. 7-deaza-dX is a useful research tool for DNA structural studies. For example, in one study on triple helix formation, the authors showed that 7-deaza-X:A-T triplets are stable and can be used to facilitate formation of triple helices in the anti-parallel motif (1). In a different study related to development of an expanded genetic alphabet, the ability of 7-deaza-dX to form non-standard base pair with an 2,4-diaminopyrimidine analog (2). Note that in both studies, their authors used H-phosphonate chemistry to incorporate 7-deaza-dX into the oligonucleotide.

References
1. Milligan, J.F., Krawczyk, S.H., Wadwani, S., Matteucci, M.D. An anti-parallel triple helix motif with oligodeoxynucleotides containing 2-deoxyguanosine and 7-deaza-2-deoxyxanthosine.Nucleic Acids Res. (1993), 21: 327-333.
2. Lutz, M.J., Held, H.A., Hottiger, M., Hubscher, U., Benner, S.A. Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet.Nucleic Acids Res. (1996), 24: 1308-1313.
- 7-deaza-dX

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