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propyne dC

picture of propyne dC

Modification : propyne dC

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



26-6501
Antisense
pdC
Y
Y
Y
327.23
7.4
PS26-6501.pdf
-
-
-


Catalog NoScalePrice
26-6501-0550 nmol$130.00
26-6501-02200 nmol$130.00
26-6501-011 umol$200.00
26-6501-032 umol$265.00
26-6501-1010 umol$1,600.00
26-6501-1515 umol$2,000.00
Discounts are available for propyne dC!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply
Related Modifications
propyne dU

It has been shown that C-5 propyne analogs of dC and dT when substituted in phosphorothioate oligonucleotide imparts greater inhibition of gene expression due to increased binding affinity to the target mRNA and increased stability. Based on the above information antisense oligonucleotide could either be Phosphorothioated at all diester linkages or combined with substitutions of dC and dT by C-5 propyne analogs pdC and pdU. The use of propyne analogs is covered by patents and licensing agreements. The sale of propyne-modified oligos is for research use only. See license agreement* - propyne dC

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