Modification : N6-Methyl dA (m6dA)
Catalog Reference Number
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
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N6-Methyl-deoxyadenosine (N6-Me-dA) is a methylated nucleoside base that to date has only been found in bacterial and protist DNA (1). In these organisms, N6-Me-dA plays several roles, including post-replicative DNA mis-match repair, chromosome compaction and regulation of gene expression (2). Adenine methylation also is essential for either the viability or virulence of a number of pathological bacterial strains (3). Because of these properties, there is considerable interest in the bacterial enzyme N6-DNA methyltransferase (which methylates adenine) as a potential target for developing new anti-microbials (4), as well as the need to confirm whether or not this enzyme is present in mammals, including human (5). N6-Me-dA-modified oligonucleotides can serve as important research tools in such studies.
1. Hattman, S. DNA-[adenine] methylation in lower eukaryotes. Biochemistry (Mosc)
2. Wion, D., Casadesus, J. N(6)-methyl-adenine: an epigenetic signal for DNA-protein interactions. Nat. Rev. Microbiol.
3. Heithoff, D.M., Sinsheimer, R.L., Low, D.A., Mahan, M.J. An essential role for DNA adenine methylation in bacterial virulence. Science
4. Mashoon, N., Carroll, M., Pruss, C., Eberhard, J., Ishikawa, S., Estabrook, R.A., Reich, N. Functional characterization of Escherichia coli DNA adenine methyltransferase, a novel target for antibiotics. J. Biol. Chem.
5. Ratel, D., Ravanat, J-L., Charles, M-P., Platet, N., Breuillaud, L., Lunardi, J., Berger, F., Wion, D. Undetectable levels of N6-methyl adenine in mouse DNA. Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase. FEBS Microbiol. Lett.
- N6-Methyl dA (m6dA)