Quick Order |All Online Ordering|Product Catalog Ordering|Oligo Modifications List|Product Info & Literature|Oligo Design Tools/Resources

N6-dimethyl rA

picture of N6-dimethyl rA

Modification : N6-dimethyl rA

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



27-6602
Others
N6-diMe rA
Y
Y
Y
333.2
15.2
PS27-6602.pdf
-
-
-


Catalog NoScalePrice
27-6602-0550 nmol$350.40
27-6602-02200 nmol$350.40
27-6602-011 umol$455.52
27-6602-032 umol$683.28
27-6602-1010 umol$3,644.16
27-6602-1515 umol$4,555.20
Discounts are available for N6-dimethyl rA!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply
Related Modifications
N6-Methyl dA
N6-Methyl rA (m6A)

N6-dimethyl-riboadenosine (N6-dimethyl rA) is a minor RNA modification found primarily in rRNA (1), and recently, in Mycobacterium tRNA (2). N6-dimethyl rA appears to play a structural role in rRNA; in 16S RNA of E. coli, two successive N6-dimethyl rA modifications are present 24 and 25 residues from the 3end, and nowhere else (3). These residues are located at the interface between the 30S and 50S subunits of 70S E. coli rRNA (1), but do not appear to play a major role in the binding of fMet-tRNA, or in initiation of protein synthesis (4). Its precise role in tRNA is yet unknown.

References
1. Politz, S.M., Glitz, D.G. Ribosome structure: Localization of N6, N6-dimethyladenosine by electron microscopy of a ribosome-antibody complex.Proc. Natl. Acad. Sci. USA. (1997), 74: 1468-1472.
2. Chan, C.T.Y., Chionh, Y.H., Ho, C-H., Lim, K.S., Babu, I.R., Ang, E., Wenwei, L., Alonso, S., Dedon, P.C. Identification of N6,N6-Dimethyladenosine in Transfer RNA from Mycobacterium bovis Bacille Calmette-Guerin. Molecules (2011), 16: 5168-5181.
3. Ehresmann, C., Stiegler, P., Mackie, G.A., Zimmermann, R.A., Ebel, J.P., Fellner, P. Primary sequence of the 16S ribosomal RNA of Eschericia coli. Nucleic Acids Res. (1975), 2: 265-278.
4. Studies on the Function of Two Adjacent N6,N6-Dimethyladenosines Near the 3 End of 16 S Ribosomal RNA of Escherichia coli. J. Biol. Chem. (1979), 254: 9090-9094.
- N6-dimethyl rA

Oligonucleotide Synthesis |  Flourescent Molecular Probes |  Gene Detection Systems |  Tools & Reagents |  Gene Assays |  RNAi
© 2017 Gene Link |  Terms & Conditions |  Licenses |  Privacy Policy |  May 28, 2017 1:27:52 AM