Modification : Thiol SS Dipod (DTSPA)Catalog Reference Number
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Thiol SS Serinol Dipod DTSPA) is a disulfide-containing modifier designed to functionalize synthetic DNA or RNA with multiple thiol groups and can be incorporated at any position of the oligonucleotide. Each DTPA addition leads to two thiol groups. This modifier was designed for optimal tethering of oligonucleotides to a gold surface but it can also be used for multiple reactions with maleimides and other thiol-specific derivatives.
After synthesis, Gene Link supplies the oligo to the customer in the oxidized (disulfide) form. The disulfide bond can then be reduced with TCEP or dithiothreitol (DTT) to generate the fully active thiolated oligo by the customer in his/her own laboratory.
See Gene Link thiol reduction technical sheet for details Thiol Reduction Protocol
- Thiol SS Serinol Dipod (DTSPA)
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