In this section: Introduction | Quality Control | Purification | Modifications | Long Oligos | Price List
In this section: Introduction | Molecular Beacon FAQ's | Fluorescent Probes Price List | Other Fluorescent Molecular Probes
In this section: SPCT | DME SPCT Intro | Order DME TaqMan® Assays SPCT | SNP PCT Search | Gene Expression Assays | SPCT Design Center | GeneAssays
In this section: RNA Oligonucleotides | Quality Control | Purification | Modifications | RNAi Explorer™ Products and Prices | Custom RNAi | RNAi Design Guidelines | SmartBase™ siRNA Modifications | shRNA Explorer™
In this section: PCR Amplification & Analysis
In this section: Introduction | Genemer™ | GeneProber™ | Prober™ Gene Detection Kits | GScan™ Gene Detection Kits | Genemer™ Control DNA | Infectious Diseases
In this section: Gene Construction
In this section: Introduction | The Omni-Clean™ System | The Omni-Pure™ Plasmid Purification System | The Omni-Pure™ Genomic DNA Purification System | Viral DNA & RNA Purification | Microbial DNA Purification | Plant DNA Purification
In this section: Introduction | Quality Control | Purification | Modifications | Long Oligos | Price List
In this section: Introduction | Molecular Beacon FAQ's | Fluorescent Probes Price List | Other Fluorescent Molecular Probes
In this section: SPCT | DME SPCT Intro | Order DME TaqMan® Assays SPCT | SNP PCT Search | Gene Expression Assays | SPCT Design Center | GeneAssays
In this section: RNA Oligonucleotides | Quality Control | Purification | Modifications | RNAi Explorer™ Products and Prices | Custom RNAi | RNAi Design Guidelines | SmartBase™ siRNA Modifications | shRNA Explorer™
In this section: PCR Amplification & Analysis
In this section: Introduction | Genemer™ | GeneProber™ | Prober™ Gene Detection Kits | GScan™ Gene Detection Kits | Genemer™ Control DNA | Infectious Diseases
In this section: Gene Construction
In this section: Introduction | The Omni-Clean™ System | The Omni-Pure™ Plasmid Purification System | The Omni-Pure™ Genomic DNA Purification System | Viral DNA & RNA Purification | Microbial DNA Purification | Plant DNA Purification
Docosahexaenoic (C22:6) DHA LMO
DHA (C22:6) LMO
Code : [3-DHA-C22-6]
-LMO.png)
Modification : DHA (C22:6) LMO
Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC
| Catalog No | Scale | Price | | 26-6626-05 | 50 nmol | $254.00 | | 26-6626-02 | 200 nmol | $286.00 | | 26-6626-01 | 1 umol | $335.00 | | 26-6626-03 | 2 umol | $394.00 | | 26-6626-06 | 5 umol | $1,507.50 | | 26-6626-10 | 10 umol | $2,133.00 | | 26-6626-15 | 15 umol | $2,500.00 |
Click here for a list Cellular Delivery Modifications.
Click here for more information on siRNA and antisense oligo modifications, design & applications.
-Docosahexaenoic-DHA (C22:6) Lipid Modified Oligo (LMO) Delivery
DHA (docosahexaenoic acid) and DCA (docosanoic acid) are fatty acids that can be conjugated to siRNA molecules to improve their delivery and efficacy, particularly in extrahepatic tissues. DHA conjugation enhances siRNA distribution in the brain and promotes cellular uptake by neurons and astrocytes. DCA conjugation facilitates efficient and sustainable gene silencing in skeletal and cardiac muscles after systemic injection.
Nikan, M., Osborn, M.F., Coles, A.H., Godinho, B.M., Hall, L.M., Haraszti, R.A.,
Hassler, M.R., Echeverria, D., Aronin, N., and Khvorova, A. (2016).
Docosahexaenoic acid conjugation enhances distribution and safety of siRNA
upon local administration in mouse brain. Mol. Ther. Nucleic Acids 5, e344.
Biscans,A., Caiazzi, J., McHugh, N., Hariharan, V., Muhuri, M., and Anastasia Khvorova (2020) Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles. Mol. Ther. 29:4
- Docosahexaenoic (C22:6) DHA LMO
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Oligo Purification