Universal Support Applications

Universal Support Applications

As described in the Introduction, the chief advantages of a universal support is that it allows the maximum possible number of moiety options at the 3’-end of a synthesized oligo, and permits synthesis of oligo with 3’-modifications that are not themselves available as a support.

References

(1) Azhayev, A.V., Antopolsky, M.L. Amide group assisted 3’-dephosphorylation of oligonucleotides synthesized on universal A-supports. Tetrahedron (2001), 57: 4977-4986.