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propyne dU

propyne dU

Code : [pdU]

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picture of propyne dU

Modification : propyne dU

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



26-6502
Antisense
[pdU]
Y
Y
Y
328.22
8.4
PS26-6502.pdf
-
-
-


Catalog NoScalePrice
26-6502-0550 nmol$105.00
26-6502-02200 nmol$105.00
26-6502-011 umol$137.00
26-6502-032 umol$205.00
26-6502-065 umol$616.50
26-6502-1010 umol$1,095.00
26-6502-1515 umol$1,369.00
Discounts are available for propyne dU!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

It has been shown that C-5 propyne analogs of dC and dT when substituted in phosphorothioate oligonucleotide imparts greater inhibition of gene expression due to increased binding affinity to the target mRNA and increased stability. Based on the above information antisense oligonucleotide could either be Phosphorothioated at all diester linkages or combined with substitutions of dC and dT by C-5 propyne analogs pdC and pdU.

Modifications Increasing Duplex Stability and Nuclease Resistance

Modification

Duplex Stability [Tm Increase]

Nuclease Resistance

Locked Analog Bases Increased [2- 4C per substitution] Increased
2-Amino-dA Increased [3.0C per substitution] Similar to DNA
C-5 propynyl-C Increased [2.8C per substitution] Increased
C-5 propynyl-U Increased [1.7C per substitution] Increased
2'-Fluoro Increased [1.8C per substitution] Increased
5-Methyl-dC Increased [1.3C per substitution] Similar to DNA
2'-O Methyl Increased Increased
Phosphorothioate Slightly decreased Increased
Click here for complete list of duplex stability modifications
The use of propyne analogs is covered by patents and licensing agreements. The sale of propyne-modified oligos is for research use only. See license agreement* - propyne dU

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