Modification : 8-Bromo GCatalog Reference Number
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
RNA Oligo Synthesis
8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the syn conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function(1). It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects (2,3).
1. R. Yajima, D. J. Proctor, R. Kierzek, et al. A conformationally restricted guanosine analog reveals the catalytic relevance of three structures of an RNA enzyme. Chemistry & Biology 14, 23-30 (2007).
2. M. G. Goodman and W. O. Weigle. Intracellular lymphocyte activation and carrier-mediated transport of C8-substituted guanine ribonucleosides. Proceedings of the National Academy of Sciences of the United States of America 81, 862-866 (1984).
3. S. Giorgio and S. C. Barao. Intracellular Leishmania amazonensis killing induced by the guanine nucleoside 8-bromoguanosine. Rev.Inst.Med.Trop.S.Paulo. 40(4), 1-9 (1998).
- 8-Bromo riboguanosine
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