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dNaM

dNaM

Code : [dNaM]

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picture of dNaM

Modification : dNaM

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



26-6561
Duplex Stability
[dNaM]
Y
Y
Y
336.74
11
PS26-6561.pdf
-
-
-


Catalog NoScalePrice
26-6561-0550 nmol$782.00
26-6561-02200 nmol$782.00
26-6561-011 umol$874.00
26-6561-032 umol$1,311.00
26-6561-065 umol$3,933.00
26-6561-1010 umol$6,992.00
26-6561-1515 umol$8,740.00
Discounts are available for dNaM!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Base pair that achieves pair recognition through hydrophobic interactions.


The dNaM and d5SICS matched pair appears to be a very interesting novel base pair. These unnatural C-nucleosides have pair recognition that rivals the A-T and G-C pairing in the natural genetic alphabet. In addition, they have been shown to be well-replicated by DNA polymerases under steady-state conditions, regardless of sequence. The fidelity and efficiency of dNaM and d5SICS replication approach those of natural synthesis. Both dNaM and d5SICS are also efficiently transcribed by T7 RNA polymerase in either direction.

dNaM IUPAC name: (1R)-1,4-Anhydro-2-deoxy-1-(3-methoxynaphthalen-2-yl)-D-erythro-pentitol. CAS Number: 1117893-19-2
d5SICS IUPAC name: 2-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-methylisoquinoline-1(2H)-thione. CAS Number: 1010689-00-5


References


1. Seo, Y.J.; Matsuda, S.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131(14), 5046-7.
2. Seo, Y.J.; Hwang, G.T.; Ordoukhanian, P.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131(9), 3246-52.
3. Seo, Y.J.; Romesberg, F.E. ChemBioChem, 2009, 10(14), 2394-2400.
4. Hwang, G.T.; Hari, Y.; Romesberg, F.E. Nucleic Acids Res., 2009, 37(14), 4757-63.
5. Hari, Y.; Hwang, G.T.; Leconte, A.M.; Joubert, N.; Hocek, M.; Romesberg, F.E. ChemBioChem, 2008, 9(17), 2796-9.
6. Hwang, G.T.; Romesberg, F.E. J. Am. Chem. Soc., 2008, 130(44), 14872-82.
7. Leconte, A.M.; Hwang, G.T.; Matsuda, S.; Capek, P.; Hari, Y.; Romesberg, F.E. J. Am. Chem. Soc., 2008, 130 (7), 2336-43.

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