Modification : d5SICS
Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC
26-6562
Duplex Stability
[d5SICS]
Y
Y
Y
353.11
11
PS26-6562.pdf
-
-
-
| Catalog No | Scale | Price |
| 26-6562-05 | 50 nmol | $1,588.00 |
| 26-6562-02 | 200 nmol | $1,588.00 |
| 26-6562-01 | 1 umol | $1,804.00 |
| 26-6562-03 | 2 umol | $2,707.00 |
| 26-6562-10 | 10 umol | $14,435.00 |
| 26-6562-15 | 15 umol | $18,044.00 |
| Discounts are available for d5SICS! |
| Modification* Discount Price Structure |
|
1 site/order
|
List price
|
|
2 sites/order
|
10% discount
|
|
3 sites/order
|
20% discount
|
|
4 sites/order
|
30% discount
|
|
5-9 sites/order
|
50% discount
|
|
10+ sites/order
|
60% discount
|
|
*Exceptions apply
|
Base pair that achieves pair recognition through hydrophobic interactions.
The dNaM and d5SICS matched pair appears to be a very interesting novel base pair. These unnatural C-nucleosides have pair recognition that rivals the A-T and G-C pairing in the natural genetic alphabet. In addition,
they have been shown to be well-replicated by DNA polymerases under steady-state conditions,
regardless of sequence. The fidelity and efficiency of dNaM and d5SICS replication approach
those of natural synthesis. Both dNaM and d5SICS are also efficiently transcribed by T7 RNA
polymerase in either direction.
dNaM IUPAC name: (1R)-1,4-Anhydro-2-deoxy-1-(3-methoxynaphthalen-2-yl)-D-erythro-pentitol. CAS Number: 1117893-19-2
d5SICS IUPAC name: 2-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-methylisoquinoline-1(2H)-thione. CAS Number: 1010689-00-5
References
1. Seo, Y.J.; Matsuda, S.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131(14), 5046-7.
2. Seo, Y.J.; Hwang, G.T.; Ordoukhanian, P.; Romesberg, F.E. J. Am. Chem. Soc., 2009,
131(9), 3246-52.
3. Seo, Y.J.; Romesberg, F.E. ChemBioChem, 2009, 10(14), 2394-2400.
4. Hwang, G.T.; Hari, Y.; Romesberg, F.E. Nucleic Acids Res., 2009, 37(14), 4757-63.
5. Hari, Y.; Hwang, G.T.; Leconte, A.M.; Joubert, N.; Hocek, M.; Romesberg, F.E.
ChemBioChem, 2008, 9(17), 2796-9.
6. Hwang, G.T.; Romesberg, F.E. J. Am. Chem. Soc., 2008, 130(44), 14872-82.
7. Leconte, A.M.; Hwang, G.T.; Matsuda, S.; Capek, P.; Hari, Y.; Romesberg, F.E. J. Am.
Chem. Soc., 2008, 130 (7), 2336-43.
- d5SICS
Oligo Purification