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8-Oxo deoxyguanosine (8-Oxo dG)

picture of 8-Oxo deoxyguanosine (8-Oxo dG)

Modification : 8-Oxo dG

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



26-6434
Minor Bases
8-Oxo dG
Y
Y
Y
345.21
5.9
PS26-6434-02.pdf
-
-
-


Catalog NoScalePrice
26-6434-0550 nmol$355.00
26-6434-02200 nmol$355.00
26-6434-011 umol$461.50
26-6434-032 umol$692.25
26-6434-1010 umol$3,692.00
26-6434-1515 umol$4,615.00
Discounts are available for 8-Oxo dG!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

8-Oxo-deoxyguanosine (8-Oxo-dG) is classified as an oxidized nucleotide, and is primarily used in studies of oxidative DNA damage and associated repair mechanisms. In the cell, 8-Oxo-dG DNA lesions are formed by reaction with reactive oxygen species (ROS) generated either via normal oxidative metabolic processes, UV ionizing radiation, or 2-nitropropane (an industrial solvent and component of tobacco smoke) (1). 8-Oxo-dG can potentially mispair with A (leading to G-to-T transversions) (2). As a single-base lesion, 8-Oxo-dG is removed by the base excision repair (BER) mechanism and the native guanine base restored (3). In the cell, 8-Oxo-dG does not appear to be strongly mutagenic (4).

References
1. Feig, D.I., Sowers, L.C., Loeb, L.A. Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA. Proc. Natl. Acad. Sci. USA. (1994), 91: 6609-6613.
2. Neeley, W.L., Essigmann, J.M. Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem. Res. Toxicol. (2006), 19: 491-505.
3. Nilsen, H., Krokan, H.E. Base excision repair in a network of defence and tolerance.Carcinogenesis (2001), 22: 987-998.
4. Kalam, M.A., Haraguchi, K., Chandani, S., Loechler, E.L., Moriya, M., Greenberg, M.M., Basu, A.K Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res. (2006), 34: 2305-2315.
- 8-Oxo deoxyguanosine (8-Oxo dG)

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