Modification : 8-Oxo dG
Catalog Reference Number
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
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8-Oxo-deoxyguanosine (8-Oxo-dG) is classified as an oxidized nucleotide, and is primarily used in studies of oxidative DNA damage and associated repair mechanisms. In the cell, 8-Oxo-dG DNA lesions are formed by reaction with reactive oxygen species (ROS) generated either via normal oxidative metabolic processes, UV ionizing radiation, or 2-nitropropane (an industrial solvent and component of tobacco smoke) (1). 8-Oxo-dG can potentially mispair with A (leading to G-to-T transversions) (2). As a single-base lesion, 8-Oxo-dG is removed by the base excision repair (BER) mechanism and the native guanine base restored (3). In the cell, 8-Oxo-dG does not appear to be strongly mutagenic (4).
1. Feig, D.I., Sowers, L.C., Loeb, L.A. Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA. Proc. Natl. Acad. Sci. USA.
2. Neeley, W.L., Essigmann, J.M. Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem. Res. Toxicol.
3. Nilsen, H., Krokan, H.E. Base excision repair in a network of defence and tolerance.Carcinogenesis
4. Kalam, M.A., Haraguchi, K., Chandani, S., Loechler, E.L., Moriya, M., Greenberg, M.M., Basu, A.K Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res.
- 8-Oxo deoxyguanosine (8-Oxo dG)