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Thymidine Glycol

picture of Thymidine Glycol

Modification : Thymidine Glycol

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



26-6487
Minor Bases
TG
Y
Y
Y
338.21
8.7
PS26-6487.pdf
-
-
-


Catalog NoScalePrice
26-6487-0550 nmol$350.00
26-6487-02200 nmol$350.00
26-6487-011 umol$410.00
26-6487-032 umol$615.00
26-6487-1010 umol$3,280.00
26-6487-1515 umol$4,100.00

Thymidine Glycol is classified as an oxidized nucleotide, and is primarily used in studies of oxidative DNA damage and associated repair mechanisms. In the cell, thymidine glycol DNA lesions are formed when the 5,6-double bond of thymidine is oxidized by oxidative metabolic processes, ionizing radiation, or industrial chemical oxidizers like potassium permanganate and osmium tetroxide. Although it does not appear to be mutagenic, it generates more structural distortion to the double helix than any other oxidatively-damaged base. Possibly as a result of this, thymidine glycol effectively blocks DNA polymerases, resulting in stalled replication forks, making it a potentially lethal lesion. However, despite the more extensive structural distortion, thymidine glycol lesions are most commonly repaired by the BER, rather than the NER mechanism (1,2).

References
1. Hatahet, Z., Wallace, S.S. Translesion DNA Synthesis. in DNA damage and repair. Volume I (1998), Humana Press: 231-232.
2. Nilsen, H., Krokan, H.E. Base excision repair in a network of defence and tolerance. Carcinogenesis (2001), 22: 987-998.
- Thymidine Glycol

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