Quick Order |All Online Ordering|Product Catalog Ordering|Oligo Modifications List|Product Info & Literature|Oligo Design Tools/Resources

Thymidine Glycol

Thymidine Glycol

Code : [Tg-Thy-Glycol]

Search Modifications Modified Oligos Quick Price Estimate
picture of Thymidine Glycol

Modification : Thymidine Glycol

Catalog Reference Number
Modification Code
5 Prime
3 Prime
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC

Minor Bases

Catalog NoScalePrice
26-6487-0550 nmol$465.00
26-6487-02200 nmol$465.00
26-6487-011 umol$543.00
26-6487-032 umol$664.00
26-6487-065 umol$1,993.50
26-6487-1010 umol$3,542.00
26-6487-1515 umol$4,428.00
Discounts are available for Thymidine Glycol !
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

Thymidine Glycol is classified as an oxidized nucleotide, and is primarily used in studies of oxidative DNA damage and associated repair mechanisms. In the cell, thymidine glycol DNA lesions are formed when the 5,6-double bond of thymidine is oxidized by oxidative metabolic processes, ionizing radiation, or industrial chemical oxidizers like potassium permanganate and osmium tetroxide. Although it does not appear to be mutagenic, it generates more structural distortion to the double helix than any other oxidatively-damaged base. Possibly as a result of this, thymidine glycol effectively blocks DNA polymerases, resulting in stalled replication forks, making it a potentially lethal lesion. However, despite the more extensive structural distortion, thymidine glycol lesions are most commonly repaired by the BER, rather than the NER mechanism (1,2).

1. Hatahet, Z., Wallace, S.S. Translesion DNA Synthesis. in DNA damage and repair. Volume I (1998), Humana Press: 231-232.
2. Nilsen, H., Krokan, H.E. Base excision repair in a network of defence and tolerance. Carcinogenesis (2001), 22: 987-998.
- Thymidine Glycol

Oligonucleotide Synthesis |  Flourescent Molecular Probes |  Gene Detection Systems |  Tools & Reagents |  Gene Assays |  RNAi
© 2024 Gene Link |  Terms & Conditions |  Licenses |  Privacy Policy |  May 29, 2024 7:33:48 PM