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2-Amino Purine deoxyribose

2-Amino Purine

Code : [2-AP]

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picture of 2-Amino Purine deoxyribose

Modification : 2-Amino Purine

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



26-6505
Others
[2-AP]
Y
Y
Y
313.21
15.4
PS26-6505.pdf
-
-
-


Catalog NoScalePrice
26-6505-0550 nmol$190.00
26-6505-02200 nmol$190.00
26-6505-011 umol$246.00
26-6505-032 umol$370.00
26-6505-065 umol$1,107.00
26-6505-1010 umol$1,971.00
26-6505-1515 umol$2,464.00
Discounts are available for 2-Amino Purine!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

2-Amino Purine (2-AP) is a fluorescent molecule that is classified as an adenine and guanine analog, and thus can pair with both thymine and cytosine bases (1,2). It is an attractive choice for use as a probe in nucleic acid secondary structural studies, both because its fluorescence is highly sensitive to the nature of the local environment, and because it usually does not significantly affect duplex stability (3). Examples include the hairpin-loop structure of the (CAG)8 repeat, involved in several neurodegenerative disorders 2-AP substituted for A (4), the G-quadruplex telomeric structure [AGGG(TTAGGG)3] 2-AP substitute for A (5). 2-AP also has been used to characterize the effects of DNA mismatch repair on mutagenesis induced by several different nucleoside analogs (6).

References
1. Jean JM, Hall KB (2001). "2-Aminopurine fluorescence quenching and lifetimes: role of base stacking". Proc. Natl. Acad. Sci. U.S.A. 98 (1): 37-41. doi:10.1073/pnas.011442198.
2. Negishi, K.; Bessho, T.; Hayatsu, H. Nucleoside and nucleobase analog mutagens. Mutat. Res. (1994), 318: 227-238.
3. Ballin, J.D., et al. Local RNA Conformational Dynamics Revealed by 2-Aminopurine Solvent Accessibility. Biochemistry (2008), 47: 7043-7052.
4. Degtyareva, N.N.; Reddish, M.J.; Sengupta, B.; Petty, J.T. Structural Studies of a Trinucleotide Repeat Sequence Using 2-Aminopurine. Biochemistry (2009), 48: 2340-2346.
5. Kimura, T.; Kawai, K.; Fujitsuka, M.; Tetsuro, M. Monitoring G-quadruplex structures and G-quadruplex-ligand complex using 2-aminopurine modified oligonucleotides. Tetrahedron (2007), 63: 3585-3590.
6. Negishi, K.; et al. Binding specificities of the mismatch binding protein, MutS, to oligonucleotides containing modified bases. Nucleic Acids Res. Supplement No. 1 (2001), 221-222.
- 2-Amino Purine deoxyribose

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