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N1-methyl pseudoUridine (m1-psi rU)

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picture of N1-methyl pseudoUridine (m1-psi rU)

Modification : N1-methyl pseudoUridine (m1-psi rU)

Catalog Reference Number
Category
Modification Code
5 Prime
3 Prime
Internal
Molecular Weight (mw)
Extinction Coeficient (ec)
Technical Info (pdf)
Absorbance MAX
Emission MAX
Absorbance EC



27-6532
Structural Studies
[m1-psi-rU]
Y
Y
Y
320.19
9.9
PS27-6532.pdf
260
-
-


Catalog NoScalePrice
27-6532-0550 nmol$496.00
27-6532-02200 nmol$496.00
27-6532-011 umol$595.00
27-6532-032 umol$766.00
Discounts are available for N1-methyl pseudoUridine (m1-psi rU)!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply

RNA methylation occurs in a large selection of RNA nucleosides and this post transcriptional modification of RNA, carried out by a variety of RNA methyltransferases, appears in a wide variety of RNA species - including tRNA, mRNA, miRNA and RNA viruses. Over 90 methylated nucleosides have been found in tRNA and these play many significant roles in tRNA structure. In addition, methylation appears to mark the tRNA as mature, preventing its degradation as well as directing localization within the cell. mRNA, modified with 1-methylpseudouridine (1-Me-Ψ ) alone or in combination with 5-methylcytidine (5-Me-C), significantly increases protein expression in cells and mouse models. 1-Me-Ψ is also a modified nucleobase that can greatly enhance the properties of mRNA by reducing immunogenicity and increasing stability. - N1-methyl pseudoUridine (m1-psi rU)

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