Well designed siRNAs are potent and specific modulators of gene expression and have immense potential in therapeutic gene silencing. Very successful design rules and algorithms have been established based on performance of hundreds of siRNA and miRNAs (miRNAs are naturally occurring and structurally resemble siRNA and use a similar silencing complex).

1. Effective cell membrane permeation.
2. Targeted delivery.
3. Nuclease resistance confers increased half-life.
4. Sustained gene silencing with increased duplex stability.
5. Minimal off-target seeding and silencing
6. Low dosage. Minimal Toxicity

Gene Link oligos are for demanding applications and consistent results. We believe that investigators who value time and have no room for an experiment to fail due to oligo quality should consider Gene Link. Our numerous quality control steps for each oligo assure confidence.
Gene Link Oligo Synthesis Division is not an "oligo factory". Each oligo is meticulously monitored during synthesis for coupling efficiency and after processing by polyacrylamide gel electrophoresis.
Gene Link specializes in long oligos. Our description of a long oligo is 180 mer to 250 mer. You are invited to compare.

Gene Link’s proprietary synthesis and processing methods for fluorescent dyes yield primers and probes of superior quality. Gene Link offers synthesis of various forms of molecular primers and probes. We provide technical service in the design of novel probes and synthesize numerous combinations of dyes, quenchers, RNA, phosphorothioate, 2'-O-methyl and chimeric probes.

Gene Link offers enhanced PCR Amplification & Analysis that includes meticulous proofing of each automated base call. A finished result is emailed rather than a ‘raw’ sequencing data. Gene Link is committed to provide superior quality products and custom services.

Gene Link is the leader in triple repeat disorder genotyping using non-radioactive based methods. We have more than a decade of expertise and have developed facile non-radioactive detection methods for safe, sensitive and reliable genotyping of human genetic disorders specifically fragile X, Huntington Disease, Myotonic Dystrophy etc. Take a look at the simple agarose and polyacrylamide gel based systems, the chemiluminescent Southern blot detection methods and the fluorescent systems for genotyping of triple repeat disorders.

Gene Link’s expertise in long oligo synthesis makes it the natural first choice for all your needs for synthetic genes & DNA Fragment Construction. The applications for long oligo and synthetic long oligo constructs include the Synthetic Genes, Synthetic Engineered Genes, DNA Fragment Constructs, Synthetic DNA Controls, Gene Mutation Functional Analysis, Fluorescent Genotyping Controls, Allelic Discrimination Controls, Genetic Disease Controls etc.

The excellent quality reagents and kits that were used in house have been added to our product list. Tested for more than a decade and offered to you as convenience reagents. These include the omni series of reagents that include a variety of DNA and RNA purification and concentration systems. Each system has been optimized for reproducible and consistent results, yielding ultra high quality DNA and RNA suitable for all molecular biology applications.

It is prudent and beneficial to incorporate the use of positive control templates for your genotyping assays. Gene Link specializes in long oligo synthesis up to 250mer in length. Longer templates can be constructed by ligation. Gene Link can provide custom synthetic oligo templates for all your genotyping and template requirements. We routinely provide expert technical assistance in the design of templates and ultra modified fluorescent probes with enhanced duplex stability and nuclease resistance.

RNAi Explorer™ Assisted - RNAi Explorer™ from Gene Link is a series of products and services to aid researchers in exploring RNA interference. The online search and design tools for siRNA or shRNA are developed based on current known guidelines. You are encouraged to try the robust search and design algorithm.